Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Preoptic angiotensin and salt appetite.

D A Fitts1, D B Masson

  • 1Department of Psychology, University of Washington, Seattle 98195.

Behavioral Neuroscience
|August 1, 1990
PubMed
Summary

Angiotensin (ANG) in the brain drives thirst and salt appetite. Research shows ANG acting in the organum vasculosum laminae terminalis (OVLT) is crucial for salt appetite, not just water intake.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of SFO lesions on salt appetite during multiple sodium depletions.

Physiology & behavior·2002
Same author

Conditioned taste aversion and c-Fos expression in cholestatic rats.

Brain research·2001
Same author

Influence of the subfornical organ on meal-associated drinking in rats.

American journal of physiology. Regulatory, integrative and comparative physiology·2001
Same author

Circumventricular organs and ANG II-induced salt appetite: blood pressure and connectivity.

American journal of physiology. Regulatory, integrative and comparative physiology·2000
Same author

The induction of c-Fos in the NTS after taste aversion learning is not correlated with measures of conditioned fear.

Behavioral neuroscience·2000
Same author

Modified Pereyra bladder neck suspension in patients with intrinsic sphincter deficiency and bladder neck hypermobility: patient satisfaction with a mean follow-up of 4 years.

Urology·2000

Area of Science:

  • Neuroscience
  • Physiology
  • Behavioral Science

Background:

  • Angiotensin (ANG) plays a vital role in regulating fluid and electrolyte balance.
  • Previous research has implicated forebrain regions in ANG-induced drinking behaviors.

Purpose of the Study:

  • To determine if angiotensin synthesis or receptor activation in the ventral preoptic region is critical for ANG-induced salt appetite in rats.
  • To differentiate the roles of the subfornical organ (SFO) and the organum vasculosum laminae terminalis (OVLT) in salt appetite.

Main Methods:

  • Experiment 1: Infusion of ANG into the SFO and OVLT in rats.
  • Experiment 2: Administration of captopril (CAP) orally and microinjection into the SFO and OVLT to manipulate ANG II synthesis.

Main Results:

  • ANG infusions into the SFO induced water drinking but not saline intake.
  • ANG infusions near the OVLT induced both water and saline drinking.
  • Captopril microinjections into the SFO reduced water drinking but not saline intake.
  • Captopril microinjections into the OVLT reduced saline intake but not water drinking.

Conclusions:

  • Forebrain areas supporting ANG-induced water drinking do not universally support salt appetite.
  • Angiotensin acting within the OVLT is critical for the development of ANG-induced salt appetite.

Related Experiment Videos