FungiDB: an integrated functional genomics database for fungi

Area of Science:

• Mycology
• Bioinformatics
• Genomics

Background:

• FungiDB provides a centralized functional genomics resource for fungal pathogens.
• It is developed in partnership with the Eukaryotic Pathogen Bioinformatic resource center (EuPathDB).
• FungiDB shares infrastructure and a user interface with EuPathDB for integrated data searching.

Purpose of the Study:

• To present the current release of FungiDB, a pan-fungal genomic database.
• To highlight the integrated genomic and functional data available for 18 fungal species.
• To emphasize FungiDB's utility for in silico experimentation.

Main Methods:

• FungiDB integrates genome sequence and annotation data from 18 fungal species.
• It incorporates functional data, including cell cycle microarray, hyphal growth RNA-sequence, and yeast two-hybrid interaction data.
• The resource utilizes a standard analysis pipeline and leverages orthology for data interpretation.

Main Results:

• The current FungiDB release includes genome data for species across Ascomycota, Basidiomycota, and Mucormycotina.
• Diverse functional datasets are integrated, enabling comprehensive analysis.
• Sophisticated, integrated searches are possible through an intuitive graphical system.

Conclusions:

• FungiDB serves as a powerful resource for in silico experimentation in fungal research.
• The integration of genomic, functional, and orthology data facilitates discovery.
• This database supports research across various fungal groups and biological processes.