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Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification
Published on: November 15, 2017
Chemical proteomics in drug discovery
1Cellzome AG, Heidelberg, Germany. Gerard.Drewes@cellzome.com
Methods in Molecular Biology (Clifton, N.J.)
|November 9, 2011
Summary
Drug discovery is inefficient. Chemical proteomics using native proteins offers a promising approach to improve drug development success rates by studying natural biological targets.
Area of Science:
- Biochemistry
- Pharmacology
- Proteomics
Background:
- Drug discovery is an unproductive and costly process, even with advancements in Omics technologies.
- Target-based drug design is the dominant industry paradigm, with growing recognition of signaling pathways' roles in health and disease.
Purpose of the Study:
- To explore the potential of proteomics-based approaches in drug discovery.
- To highlight the impact of chemical proteomics assays utilizing native endogenous proteins.
Main Methods:
- Focus on proteomics-based strategies for drug target identification.
- Utilizing chemical proteomics assays with native, endogenous proteins under physiological conditions.
Main Results:
- Proteomics approaches, particularly chemical proteomics, show significant potential to enhance drug discovery.
- The use of native endogenous proteins in assays is crucial for successful application.
Conclusions:
- Chemical proteomics using native proteins can substantially impact and improve the drug discovery and development pipeline.
- This approach offers a complementary strategy to existing drug discovery techniques.
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