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Arterial segmental vasoconstriction in hypercholesterolaemic patients.

S Nilsson1, I Berglund, A Christoffersson

  • 1Department of Diagnostic Radiology, University of Uppsala, Sweden.

Acta Radiologica (Stockholm, Sweden : 1987)
|July 1, 1990
PubMed
Summary

Arterial segmental vasoconstriction (ASV), a wave-like artery narrowing, was found more frequently in hypercholesterolaemic patients. These patients were younger with lower blood pressure and less atherosclerosis.

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Area of Science:

  • Vascular Biology
  • Medical Imaging
  • Cardiovascular Disease

Background:

  • Arterial segmental vasoconstriction (ASV) is a recognized phenomenon in medium-sized arteries.
  • Previous clinical observations of ASV are less frequent than suggested by experimental data.

Purpose of the Study:

  • To investigate the frequency and characteristics of ASV in hypercholesterolaemic patients.
  • To explore potential correlations between ASV and patient demographics or disease markers.

Main Methods:

  • Digitization and quantitative computer-assisted analysis of superficial femoral artery arteriograms.
  • Inclusion of 107 hypercholesterolaemic patients from the Probucol Quantitative Regression Swedish Trial (PQRST).

Main Results:

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  • ASV was identified in 13% of hypercholesterolaemic patients, a higher frequency than previously reported.
  • ASV patients were younger, had lower blood pressure, and less atherosclerosis compared to non-ASV patients.
  • ASV was absent in patients with peripheral vascular disease symptoms or arterial occlusions.

Conclusions:

  • Hypercholesterolaemia may be associated with increased vasoreactivity, leading to a higher prevalence of ASV.
  • ASV appears inversely related to established atherosclerosis and may indicate a different vascular phenotype.
  • Further research into ASV quantification and its clinical implications is warranted.