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Soft-tissue sarcoma and pesticides exposure in men: results of a Canadian case-control study
Punam Pahwa1, Chandima P Karunanayake, James A Dosman
1Department of Community Health & Epidemiology and Canadian Centre for Health and Safety in Agriculture, University of Saskatchewan, Saskatoon, Saskatchewan, Canada. pup165@mail.usask.ca
Objectives:
The objective was to investigate the putative associations of specific pesticides with soft-tissue sarcoma (STS).
Methods:
A Canadian population-based case-control study conducted in six provinces was used in this analysis. The study design consisted of two stages: a self-administered postal questionnaire and a telephone interview for those reporting pesticides exposure of 10 hours per year or more; and a 15% random sample of the remainder. Conditional logistic regression was used to fit the statistical models.
Results:
A positive history of cancer among first-degree relatives and exposure to aldrin and diazinon were statistically significant independent predictors of an increased risk for STS, whereas diagnosis of whopping cough lowered the risk of STS.
Conclusions:
The incidence of STS was associated with specific insecticides after adjustment for other independent predictors.
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