Related Experiment Video
Updated: May 27, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
Controversy over the classification of medication-overuse headache.
1Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Avenida das Américas 1155, Room 504, CEP 22631-000, Rio de Janeiro, Brazil. vincent@ufrj.br
Medication-overuse headache (MOH) is a common disorder affecting 1-2% of the population. Current diagnostic criteria for MOH are less restrictive, allowing diagnosis without medication withdrawal confirmation.
Area of Science:
- Neurology
- Clinical Medicine
Background:
- Medication-overuse headache (MOH) affects 1-2% of the population.
- MOH is characterized by daily or near-daily headaches due to chronic acute medication use.
- Diagnosing MOH is challenging due to the absence of objective biomarkers.
Purpose of the Study:
- To review and discuss the current diagnostic criteria for MOH.
- To emphasize the clinical and pathophysiological basis of MOH as a distinct secondary headache disorder.
Main Methods:
- Review of clinical grounds and existing research on MOH.
- Analysis of the evolution of diagnostic criteria for MOH.
Main Results:
- Current MOH diagnostic criteria are less restrictive than previous versions.
- Diagnosis is now possible without requiring confirmation after medication withdrawal.
- MOH remains a distinct secondary disorder based on clinical and pathophysiological evidence.
Conclusions:
- MOH is a significant secondary headache disorder.
- Diagnostic criteria have evolved, becoming less restrictive.
- Further research is needed in this field.
Related Concept Videos
Drug Classes and Categories
Prescription, Nonprescription and Orphan Drugs
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
Drug Abuse and Addiction: Pharmacological Phenomena
Substance Use Disorders Affecting Sleep
Understanding the concepts of physical dependence,...
Classification of Skeletal Muscle Relaxants
Peripherally acting skeletal muscle relaxants interfere with the neurotransmission at the neuromuscular end plate to induce paralysis during...
Therapeutic Drug Monitoring: Overview and Classification

