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Related Experiment Videos

Neural control of renal hemodynamics and function during development.

J E Robillard1, F G Smith, K T Nakamura

  • 1Department of Pediatrics, College of Medicine, University of Iowa, Iowa City.

Pediatric Nephrology (Berlin, Germany)
|July 1, 1990
PubMed
Summary

The renal sympathetic nervous system develops early and influences kidney function in fetuses and newborns. Its role in fetal hemodynamics and sodium balance is crucial for developing renal function.

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Area of Science:

  • Developmental Biology
  • Physiology
  • Nephrology

Background:

  • The renal sympathetic nervous system's role in kidney development is not fully understood.
  • Early renal innervation suggests a potential role in fetal kidney maturation.

Purpose of the Study:

  • To review current knowledge on the renal sympathetic nervous system's function during development.
  • To explore its impact on fetal and neonatal renal hemodynamics, sodium balance, and renin secretion.

Main Methods:

  • Review of recent scientific literature and studies on fetal and neonatal sheep models.
  • Analysis of renal nerve stimulation effects under various conditions, including alpha-adrenoceptor blockade.

Main Results:

  • Renal innervation is present early in fetal life, potentially aiding cellular development.

Related Experiment Videos

  • Renal nerve stimulation impacts fetal and neonatal renal blood flow and vascular resistance differently than in adults.
  • Renal nerves modulate natriuretic response and sodium reabsorption in developing kidneys.

    • Conclusions:

    • The renal sympathetic nervous system plays a significant role in fetal and neonatal kidney development and function.
    • Understanding these early influences is critical for comprehending long-term renal health and potential stress responses.