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Published on: February 15, 2019
Cyclopiazonic acid biosynthesis of Aspergillus flavus and Aspergillus oryzae
Perng-Kuang Chang1, Kenneth C Ehrlich, Isao Fujii
1Southern Regional Research Center, Agricultural Research Service, US Department of Agriculture, 1100 Robert E. Lee Boulevard, New Orleans, LA 70124, USA. perngkuang.chang@ars.usda.gov
Abstract:
Cyclopiazonic acid (CPA) is an indole-tetramic acid neurotoxin produced by some of the same strains of A. flavus that produce aflatoxins and by some Aspergillus oryzae strains. Despite its discovery 40 years ago, few reviews of its toxicity and biosynthesis have been reported. This review examines what is currently known about the toxicity of CPA to animals and humans, both by itself or in combination with other mycotoxins. The review also discusses CPA biosynthesis and the genetic diversity of CPA production in A. flavus/oryzae populations.
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