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Updated: May 27, 2026

High-throughput Screening for Small-molecule Modulators of Inward Rectifier Potassium Channels
Published on: January 27, 2013
From toxins targeting ligand gated ion channels to therapeutic molecules
Adak Nasiripourdori1, Valérie Taly, Thomas Grutter
1Department of Biology, Faculty of Sciences, Arak University, Iran. nasiripour_a@yahoo.com
Abstract:
Ligand-gated ion channels (LGIC) play a central role in inter-cellular communication. This key function has two consequences: (i) these receptor channels are major targets for drug discovery because of their potential involvement in numerous human brain diseases; (ii) they are often found to be the target of plant and animal toxins. Together this makes toxin/receptor interactions important to drug discovery projects. Therefore, toxins acting on LGIC are presented and their current/potential therapeutic uses highlighted.
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