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Published on: May 4, 2017

Certolizumab: efficacy and safety profile of a novel pegylated TNF-alpha blocking agent

Ennio Lubrano1, Antonio Spadaro

  • 1Dipartimento di Scienze per la Salute, Università del Molise, Campobasso, Italy. enniolubrano@hotmail.com

Acta Bio-Medica : Atenei Parmensis
|November 11, 2011
PubMed

The treatment of Rheumatoid Arthritis (RA) has changed since the introduction of biological agents. In particular, the anti Tumor Necrosis Factor (TNF)-alpha molecules have been the first group of drugs showing a good efficacy and safety profile. Among these, a new anti TNF-alpha antibody has been recently indicated for the treatment of RA: certolizumab pegol (CZP). In the main clinical trials this new pegylated anti TNF-alpha has shown to be efficacious on clinical, functional and prevention of structural damage in patients with active RA and with inadequate response to traditional disease modifying drugs, including methotrexate. Moreover CZP showed to be well tolerated and most adverse events occurred were mild or moderate. Therefore, results obtained showed that this new molecule can play a role in the treatment of RA.

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