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Updated: May 27, 2026

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Published on: August 3, 2022
Bioactive eunicellin-based diterpenoids from the soft coral Cladiella krempfi
Chi-Jen Tai1, Jui-Hsin Su2,3, Ming-Shyan Huang4,5
1These authors contributed equally to the work..
Abstract:
Four new eunicellin-based diterpenoids, krempfielins A-D (1-4), along with two known compounds (5 and 6) have been isolated from a soft coral Cladiella krempfi. The structures of the new metabolites were elucidated by extensive spectroscopic analysis and by comparison with spectroscopic data of related known compounds. Compounds 5 and 6 were shown to exhibit cytotoxicity against a limited panel of cancer cell lines. Furthermore, compounds 2, 3, 5 and 6 were shown to exert significant in vitro anti-inflammatory activity against LPS-stimulated RAW264.7 macrophage cells.
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