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A General Method for Detecting Nitrosamide Formation in the In Vitro Metabolism of Nitrosamines by Cytochrome P450s
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A prodrug approach to improve the physico-chemical properties and decrease the genotoxicity of nitro compounds

Man Chin Chung1, Priscila Longhin Bosquesi, Jean Leandro dos Santos

  • 1Lapdesf- Laboratory of Drug Desing, Dept of Drugs and Medicines, School of Pharmaceutical Sciences, University of São Paulo State, Rodovia Araraquara- Jaú km1, cep 14802-901, Araraquara, SP, Brazil. chungmc@fcfar.unesp.br

Current Pharmaceutical Design
|November 15, 2011
PubMed

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Prodrugs are a class of pharmaceutical compounds that undergo a biotransformation process within the body to be converted into a pharmacologically active drug. Prodrugs are designed to improve the therapeutic properties of the parent drug, such as enhancing bioavailability, increasing stability, or reducing toxicity. The concept of prodrugs revolves around modifying the chemical structure of the original drug to make it more effective or convenient for administration.
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Phase I biotransformation reductive reactions are chemical processes that modify drugs by introducing or revealing polar functional groups via reduction. Enzymes called reductases catalyze these reactions, playing a pivotal role in drug metabolism by transforming lipophilic drugs into more polar, water-soluble metabolites for easy excretion. An essential type of reductive reaction is the carbonyl group reduction, where aldehydes and ketones are reduced to alcohols. An example is the...
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