Related Experiment Video
Updated: Aug 6, 2026

Antimicrobial Characterization of Advanced Materials for Bioengineering Applications
Published on: August 4, 2018
Chemical innovation and scaffold refinement in FDA-approved antibiotics (2015-2025)
Andressa Franciélli Bonjorno1, Diogo Boreski1, Guilherme F S Fernandes2
1School of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara, 14800903, Brazil.
Abstract:
Antimicrobial resistance (AMR) is eroding the effectiveness of our current antibiotic arsenal and threatens to outpace drug discovery efforts worldwide. Against this backdrop, the development of antibiotics with novel mechanisms of action and optimized chemical scaffolds has never been more critical. Recent approvals by the U.S. Food and Drug Administration (FDA) showcase how medicinal chemistry is driving innovation to counter multidrug-resistant (MDR) pathogens. In this review article, we examined the structural frameworks, structure-activity relationships (SARs), and pharmacokinetic and pharmacodynamic profiles of these agents, and highlighted forward-looking strategies such as siderophore-mediated uptake and non-traditional bacterial targets, including topoisomerases. We also discuss how targeted chemical modifications have expanded the antibacterial spectrum, enhanced binding affinity, and strengthened resistance profiles. Together, these advances illustrate the central role of medicinal chemistry in reshaping the antibiotic pipeline and sustaining therapeutic efficacy amid the AMR crisis.
Related Concept Videos
FDA Approved Drugs: Changes to Approved Drugs
Production of Antibiotics
Mechanism of Antibiotic Resistance in MRSA
Bioreactor Controls-III
Clinical Significance of Antibiotic Resistance
Production of Pharmaceuticals

