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Related Concept Videos

Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin studies.
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within the...
Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
Schizophrenia01:17

Schizophrenia

Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those diagnosed.
Molecular Factors Affecting Cell Division01:27

Molecular Factors Affecting Cell Division

Several external and internal factors influence the initiation and inhibition of cell division. For instance, the death of nearby cells or the release of human growth hormone (hGH) promotes cell division. In contrast, lack of hGH or crowding of cells can inhibit cell division.
Several proteins function as internal regulators to ensure each cell cycle stage is completed faithfully before proceeding to the next. Regulator molecules may act directly or influence the activity or production of other...
Psychological and Sociocultural Causes of Schizophrenia01:29

Psychological and Sociocultural Causes of Schizophrenia

Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...

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Related Experiment Video

Updated: May 27, 2026

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra
05:14

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Published on: September 8, 2021

Altered cell cycle dynamics in schizophrenia.

Yongjun Fan1, Greger Abrahamsen, John J McGrath

  • 1National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Queensland, Australia.

Biological Psychiatry
|November 15, 2011
PubMed
Summary
This summary is machine-generated.

Schizophrenia patients exhibit altered cell cycle dynamics in olfactory neural stem cells, with faster proliferation and increased cyclin expression. These findings suggest potential impacts on neurodevelopmental trajectories.

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Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols
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Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols

Published on: June 6, 2017

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Last Updated: May 27, 2026

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra
05:14

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Published on: September 8, 2021

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols
12:02

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols

Published on: June 6, 2017

Area of Science:

  • Neuroscience
  • Cell Biology
  • Psychiatry

Background:

  • The olfactory mucosa contains neural stem cells that regenerate throughout life.
  • Previous studies showed increased mitosis in olfactory cultures from schizophrenia patients.
  • Schizophrenia-related neural stem/progenitor cells display altered cell cycle gene and protein expression.

Purpose of the Study:

  • To investigate cell cycle dynamics in olfactory neurosphere-derived cells from schizophrenia patients and healthy controls.
  • To analyze cell proliferation, cell cycle period, and cyclin protein expression.

Main Methods:

  • Olfactory neurosphere-derived cells from nine schizophrenia patients and nine controls were used.
  • Cell cycle arrest via serum deprivation, followed by cell count analysis over 96 hours.
  • Flow cytometry for cell cycle phase analysis and Western blot for cyclin protein expression.

Main Results:

  • Schizophrenia-derived cells showed increased proliferation rates and a shorter cell cycle period.
  • All cell cycle phases were phase-shifted by 2 hours in schizophrenia cells.
  • Elevated levels of cyclins D1, E, and A2 were observed in schizophrenia-derived cells.

Conclusions:

  • Schizophrenia is linked to subtle cell cycle dynamic alterations, including a shortened cell cycle and increased G1/S phase cyclins.
  • These cell cycle changes may influence brain development and neurodevelopmental trajectories in schizophrenia.
  • Olfactory neurosphere-derived cells offer a model for studying schizophrenia-associated cellular mechanisms.