Related Experiment Video
Updated: May 27, 2026

Estimation of Urinary Nanocrystals in Humans using Calcium Fluorophore Labeling and Nanoparticle Tracking Analysis
Published on: February 9, 2021
Oral manifestations of hyperoxaluria
Eliete Neves da Silva Guerra1, Leonora Vianna, Maria Nazareth Sobreira
1Department of Dentistry, School of Healthy Sciences, Universityof Brasilia, Asa Norte, Brasilia, Brazil. elieteneves@unb.br
Abstract:
Primary hyperoxaluria is a rare, inherited autosomal recessive disease caused by defects in the metabolism of glyoxylate. Oral manifestations of hyperoxaluria are rare. However, bone and tooth resorption may be the result of chronic inflammation and the presence of osteoclastic cells surrounding the oxalate crystal deposit. A deposit of calcium oxalate in the periodontium was identified in a patient with end-stage renal disease. Dental radiographs indicated bone loss and external tooth resorption. Radiolucent image in the inferior incisor region was observed and removed. The tissue showed granulomatous inflammation with foreign body reaction and associated crystalline deposits. When viewed in polarized light, these deposits are green and presented a birefringent aspect, which were interpreted as calcium oxalate crystals compatible with oxaluria. Oral manifestations of hyperoxaluria are of particular interest because of the unusual location of the oxalate crystal deposition, resulting in aggressive tooth resorption and alveolar bone loss, which may be misdiagnosed.
Related Concept Videos
Chronic Kidney Disease II: Clinical Manifestations
Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations
Diabetic Ketoacidosis l: Introduction
Peptic Ulcer Disease III: Clinical Manifestations and Complications
Urine Studies I: Urinalysis