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[Pityriasis rubra pilaris after vaccination]
B Naciri Bennani1, H Cheikh Rouhou, J Waton
1Service de dermatologie, hôpitaux de Brabois, bâtiment Philippe-Canton, 4, rue du Morvan, 54500, Vandoeuvre-les-Nancy, France. nbbouchra1979@hotmail.com
Annales De Dermatologie Et De Venereologie
|November 15, 2011
Summary
Pityriasis rubra pilaris (PRP) is rarely reported after vaccination. This case details a 17-month-old infant who developed PRP two weeks post-measles-mumps-rubella (MMR) vaccination, highlighting a potential vaccine-related trigger.
Area of Science:
- Dermatology
- Immunology
- Vaccinology
Background:
- Pityriasis rubra pilaris (PRP) is a rare chronic skin disorder.
- Post-vaccination onset of PRP is exceptionally uncommon, with limited literature.
- The measles-mumps-rubella (MMR) vaccine has not been previously associated with PRP development.
Observation:
- A 17-month-old infant presented with a diffuse, erythematous, scaly rash and follicular papules.
- The infant also exhibited characteristic orange palmoplantar keratoderma.
- Clinical presentation was highly suggestive of PRP, confirmed by non-specific histological findings.
Findings:
- The infant received an MMR vaccination two weeks prior to the rash onset.
- This represents the third reported case of vaccine-associated PRP and the first linked to MMR.
- Previous cases involved diphtheria-tetanus-polio and anti-influenza vaccines.
Implications:
- Vaccination may act as a trigger for PRP through immunological or parainfectious mechanisms.
- Detailed vaccination history is crucial for diagnosing and understanding PRP onset.
- Further research is needed to elucidate the link between vaccines and PRP development.
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