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Updated: May 27, 2026
Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus
Published on: March 8, 2015
Centromedian thalamic nuclei deep brain stimulation in refractory status epilepticus
Antonio Valentín1, Huy Q Nguyen, Alena M Skupenova
1Department of Clinical Neuroscience, Institute of Psychiatry, King's College London, London, United Kingdom. antonio.valentin@kcl.ac.uk
Background:
Refractory status epilepticus (RSE) is associated with high mortality. We report a potential treatment alternative.
Hypothesis:
Deep brain stimulation (DBS) of the centromedian thalamic nuclei (CMN) can be effective in the treatment of RSE.
Methods:
Report of the evolution of RSE after DBS of the CMN in a 27-year-old man.
Results:
In the course of an encephalopathy of unknown origin, and after a cardiac arrest, the patient developed RSE with myoclonic jerks and generalized tonic-clonic seizures. The EEG showed continuous generalized periodic epileptiform discharges (GPEDS). Five weeks after RSE onset, bilateral DBS of the CMN was started. This treatment was immediately followed by disappearance of tonic-clonic seizures and GPEDS, suggesting a resolution of RSE. The patient continued having multifocal myoclonic jerks, probably subcortical in origin, which resolved after 4 weeks. The patient remained clinically stable for 2 months in a persistent vegetative state.
Conclusions:
The remission of RSE, the abolition of GPEDS, and the patient survival suggest that DBS of the CMN may be efficacious in the treatment of refractory, generalized status epilepticus.
