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Asymmetrical Flow Field-Flow Fractionation for Sizing of Gold Nanoparticles in Suspension
Published on: September 11, 2020
Rheological and dielectric properties of different gold nanoparticle sizes
Mohamed Anwar K Abdelhalim1, Mohsen M Mady, Magdy M Ghannam
1Department of Physics and Astronomy, College of Science, King Saud University, PO 2455, Riyadth 11451, Saudi Arabia. abdelhalimmak@yahoo.com
Lipids in Health and Disease
|November 15, 2011
Summary
Gold nanoparticle (GNP) size significantly impacts viscosity and dielectric properties in aqueous solutions. Larger GNPs exhibit higher viscosity, while dielectric dispersion is GNP size-dependent, with conductivity and relaxation time decreasing as size increases.
Area of Science:
- Nanotechnology
- Materials Science
- Biomedical Engineering
Background:
- Gold nanoparticles (GNPs) are crucial for diagnostics, drug delivery, and biomedicine, but their clinical safety is a concern.
- Nanoparticle size critically influences uptake and cellular internalization.
- Rheological properties are vital for nano-fluid circulation, affecting pressure drop and pumping power, yet remain largely undocumented for GNPs.
Purpose of the Study:
- To investigate the rheological properties of different gold nanoparticle (GNP) sizes in aqueous solutions.
- To characterize the dielectric properties of various GNP sizes.
- To establish the relationship between GNP size and their rheological and dielectric behavior.
Main Methods:
- Utilized 10, 20, and 50 nm gold nanoparticles (GNPs).
- Measured rheological parameters including viscosity, shear stress, shear rate, plastic viscosity, yield stress, consistency index, and activation energy using a Brookfield LVDV-III Programmable rheometer.
- Analyzed dielectric properties within the 20-100 kHz frequency range.
Main Results:
- GNPs demonstrated Newtonian behavior with a linear relationship between shear stress and shear rate.
- Larger GNPs (50 nm) exhibited higher viscosity compared to smaller ones (10 and 20 nm).
- Viscosity decreased with increasing temperature for all GNP sizes; conductivity and relaxation time decreased with increasing GNP size.
Conclusions:
- GNP size significantly influences viscosity and dielectric properties, particularly dielectric dispersion.
- The observed decrease in relaxation time is likely due to increased localized charge distribution, supported by conductivity data.
- Further in vivo studies in rats are recommended to assess GNP behavior after administration via different routes.
