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Related Concept Videos

Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...
Venous Thrombosis I: Introduction01:30

Venous Thrombosis I: Introduction

Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...

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Updated: May 27, 2026

Isolation and Identification of Vascular Endothelial Cells from Distinct Adipose Depots for Downstream Applications
09:00

Isolation and Identification of Vascular Endothelial Cells from Distinct Adipose Depots for Downstream Applications

Published on: June 10, 2022

Thrombosis and obesity: cellular bases.

Roberto Lorenzet1, Emanuela Napoleone, Antonella Cutrone

  • 1Laboratori di Ricerca, Fondazione di Ricerca e Cura Giovanni Paolo II, Largo Gemelli, 1, 86100 Campobasso, Italy. roberto.lorenzet@rm.unicatt.it

Thrombosis Research
|November 15, 2011
PubMed
Summary

Obesity is a growing public health concern linked to inflammation and blood clotting issues. Research suggests hormones from fat cells (adipokines) and tissue factor may explain obesity

Related Experiment Videos

Last Updated: May 27, 2026

Isolation and Identification of Vascular Endothelial Cells from Distinct Adipose Depots for Downstream Applications
09:00

Isolation and Identification of Vascular Endothelial Cells from Distinct Adipose Depots for Downstream Applications

Published on: June 10, 2022

Area of Science:

  • Metabolic research
  • Cardiovascular science
  • Oncology

Background:

  • Rising global obesity rates present significant public health challenges.
  • Obesity is an independent risk factor for coronary heart disease and various cancers.
  • The pro-inflammatory and pro-thrombotic states associated with obesity require further investigation.

Purpose of the Study:

  • To explore the underlying mechanisms linking obesity to cardiovascular disease and cancer.
  • To investigate the role of adipokines and tissue factor in obesity-related pathologies.

Main Methods:

  • Review of epidemiological and cohort studies.
  • Analysis of the proposed roles of adipokines and tissue factor in obesity.

Main Results:

  • Obesity is associated with increased inflammation and a pro-thrombotic state.
  • Adipokines, secreted by adipocytes, modulate metabolism and inflammation.
  • Tissue factor is implicated in atherothrombosis and tumor biology.

Conclusions:

  • Adipokines and tissue factor are key molecules potentially explaining the link between obesity and disease.
  • Further research is needed to fully elucidate these complex associations.