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A Composite Low-Grade Inflammation Score and Cancer Outcomes: Results from the Moli-sani Study
Simona Costanzo1,2, Augusto Di Castelnuovo1, Marialaura Bonaccio1
1Research Unit of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, Italy.
Summary
Higher inflammation scores are linked to increased cancer hospitalization and colorectal cancer (CRC) risk. This suggests subclinical inflammation may predict cancer, highlighting inflammation monitoring for prevention.
Area of Science:
- Epidemiology
- Oncology
- Immunology
Background:
- Low-grade inflammation is linked to chronic diseases, but its cancer association is debated.
- This study investigates the link between a composite inflammation score and cancer outcomes.
Purpose of the Study:
- To assess the association between the INFLA-score and cancer mortality, hospitalization, and colorectal cancer (CRC).
- To evaluate subclinical inflammation as a potential prognostic indicator for cancer.
Main Methods:
- Prospective analysis of 18,933 cancer-free individuals from the Moli-sani cohort.
- INFLA-score derived from C-reactive protein, granulocyte-to-lymphocyte ratio, leukocyte, and platelet counts.
- Multivariable Cox models estimated hazard ratios for cancer outcomes across INFLA-score fifths.
Main Results:
- Highest INFLA-score fifth associated with increased cancer mortality (HR 1.19) and hospitalization (HR 1.21).
- Significantly higher hazard for colorectal cancer (CRC) in the highest INFLA-score group (HR 1.68).
- Associations were more pronounced in older individuals, those with family history, and women for CRC.
Conclusions:
- Elevated INFLA-score is associated with increased risk of cancer hospitalization and CRC.
- Subclinical inflammation may serve as a prognostic cancer indicator.
- Inflammation monitoring and lifestyle interventions could play a role in cancer prevention.
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