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Updated: May 27, 2026

A Murine Model of Carotid Aneurysm Formation

A Murine Model of Carotid Aneurysm Formation

Published on: September 9, 2025

Meta-analysis of microarray gene expression studies on intracranial aneurysms.

C Roder¹, H Kasuya, A Harati

¹Department of Neurosurgery, University of Tübingen, Hoppe-Seyler-Str. 3, 72076 Tübingen, Germany.

|November 15, 2011

Summary

This summary is machine-generated.

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Genomic factors significantly contribute to intracranial aneurysms (IAs). A meta-analysis of gene expression studies identified seven key genes potentially involved in IA development, offering new insights into disease mechanisms.

Area of Science:

Neurology
Genomics
Molecular Biology

Background:

Intracranial aneurysms (IAs) are a major cause of neurological disability and death.
Despite treatment advances, patient outcomes remain poor, suggesting a significant role for genetic factors.
Genomic studies, particularly microarray gene expression analysis, are crucial for understanding IA development.

Purpose of the Study:

To conduct a meta-analysis of existing microarray gene expression studies on intracranial aneurysms.
To identify genes consistently altered in IA tissue compared to healthy controls.
To pinpoint potential genetic markers and pathways involved in IA pathogenesis.

Main Methods:

Systematic review and meta-analysis of five published microarray gene expression studies on intracranial aneurysms.

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Last Updated: May 27, 2026

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Microsurgical Creation of Giant Bifurcation Aneurysms in Rabbits for the Evaluation of Endovascular Devices

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Analysis of gene expression data from a total of 60 IA tissue samples (30 ruptured, 30 unruptured) versus control tissue.

Functional pathway analysis to explore the biological relevance of identified genes.

Main Results:

A total of 507 differentially expressed genes were identified across the studies.
Fifty-seven genes showed altered expression in more than two studies.
Seven genes (BCL2, COL1A2, COL3A1, COL5A2, CXCL12, TIMP4, TNC) were consistently altered in more than three studies, indicating strong potential involvement in IA genesis.

Conclusions:

The meta-analysis highlights seven specific genes as highly likely contributors to the development of intracranial aneurysms.
These identified genes represent promising targets for further research into the molecular mechanisms underlying IA formation and rupture.
Understanding the role of these genes may lead to improved diagnostic or therapeutic strategies for IA patients.