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A Preclinical Model of Sepsis-Induced Myopathy with Disuse in Mice

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Perthes' disease: deprivation and decline.

Daniel C Perry¹, Colin E Bruce, Daniel Pope

¹Department of Children's Orthopaedic Surgery, Alder Hey Children's Hospital, Eaton Road, Liverpool, L12 2AP, UK. danperry@doctors.org.uk

Archives of Disease in Childhood

|November 15, 2011

Summary

Incidence of Perthes' disease declined significantly in Merseyside, UK, especially in deprived areas. This suggests environmental factors play a key role in this childhood hip disorder.

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Area of Science:

Pediatric Orthopedics
Epidemiology
Environmental Health

Background:

Perthes' disease is a childhood hip disorder leading to early osteoarthritis and joint replacement.
Merseyside, UK, has the highest reported incidence of Perthes' disease globally.
A unique disease register is maintained in Merseyside.

Purpose of the Study:

To analyze temporal trends in Perthes' disease incidence within Merseyside.
To investigate the correlation between disease incidence and socioeconomic deprivation.

Main Methods:

A descriptive observational study was conducted using data from a regional Perthes' disease register.
The study period spanned from 1976 to 2009.
Data included 1082 children diagnosed with Perthes' disease.

Main Results:

A significant decline in Perthes' disease incidence was observed in Liverpool and Knowsley over the study period.
Incidence rates remained stable in the more affluent area of Sefton.
A strong association was found between higher disease incidence and increased area deprivation, with the most deprived areas showing over three times the incidence of the most affluent areas.

Conclusions:

Perthes' disease incidence has markedly decreased, particularly in deprived regions.
The strong correlation with deprivation and changing incidence rates points to environmental factors as significant etiological determinants.
Further research into environmental influences is warranted for understanding and potentially preventing Perthes' disease.