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Assessment of Respiratory Function in Conscious Mice by Double-chamber Plethysmography

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Published on: July 10, 2018

Measures of asthma control.

Christian Bime¹, Jessica Nguyen, Robert A Wise

¹Johns Hopkins University School of Medicine and Johns Hopkins University Bloomberg School of Public Health, 5501 Hopkins Bayview Circle, Baltimore, MD 21224,USA.

Current Opinion in Pulmonary Medicine

|November 15, 2011

Summary

This summary is machine-generated.

Achieving well-controlled asthma is the primary goal of therapy. This review details tools for assessing asthma control in clinical practice and research, aiding in therapy evaluation.

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Area of Science:

Pulmonology
Clinical Medicine
Respiratory Research

Background:

Asthma control is now recognized as distinct from asthma severity.
Well-controlled asthma is the therapeutic objective for all patients.
This review focuses on assessing asthma control in clinical practice and research.

Purpose of the Study:

To provide a comprehensive overview of tools for assessing asthma control.
To guide the selection of appropriate assessment methods in clinical studies and routine care.
To support the evaluation of asthma therapy response.

Main Methods:

Review of validated questionnaires for asthma control assessment in adults and children.
Examination of asthma-specific quality-of-life measures.
Analysis of biomarkers reflecting airway eosinophilic inflammation.

Main Results:

Numerous asthma control questionnaires are validated in adults; validation is less extensive in children.
Significant overlap exists between asthma control and quality-of-life measures.
Biomarkers for eosinophilic inflammation are used as intermediate outcomes, with ongoing debate on their optimal integration into treatment algorithms.

Conclusions:

This review serves as a resource for selecting appropriate tools to assess asthma control in clinical studies.
It aids in the methodical assessment of treatment response in routine clinical care.
It supports researchers in designing studies to evaluate asthma therapies effectively.