Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Randomized Experiments01:13

Randomized Experiments

The randomization process involves assigning study participants randomly to experimental or control groups based on their probability of being equally assigned. Randomization is meant to eliminate selection bias and balance known and unknown confounding factors so that the control group is similar to the treatment group as much as possible. A computer program and a random number generator can be used to assign participants to groups in a way that minimizes bias.
Simple randomization
Simple...
Bioavailability Study Design: Single Versus Multiple Dose Studies01:11

Bioavailability Study Design: Single Versus Multiple Dose Studies

Bioavailability studies are essential for understanding how a drug is absorbed, distributed, metabolized, and excreted in the body. These studies assess the extent and rate at which the active pharmaceutical agent becomes available at the site of action. The design of bioavailability studies can involve single-dose or multiple-dose regimens, each with distinct advantages and limitations.Single-dose studies are the preferred approach due to their simplicity and reduced drug exposure for...
Bioavailability Study Design: Healthy Subjects Versus Patients01:15

Bioavailability Study Design: Healthy Subjects Versus Patients

Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...
Clinical Trials01:16

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sexual Dimorphism and Population Variation in Median Nerve Morphometry: A Multi-Institutional Cadaveric Analysis.

Diagnostics (Basel, Switzerland)·2026
Same author

International multisite implementation of distributed cell-free protein biomanufacturing to advance health and research equity.

Science advances·2026
Same author

The Role of Fathers in the Intergenerational Transmission of Obesity.

Current obesity reports·2026
Same author

A randomized, open-label phase II non-inferiority study of niraparib maintenance after 3 versus 6 cycles of platinum-based chemotherapy in patients with completely debulked advanced HRD-positive high-grade ovarian cancer in first-line therapy (N-PLUS/NOGGO-ov53/ENGOT-ov62).

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society·2026
Same author

The Factors Governing Metal Dependence of an Emergent Superfamily of Bimetallic Oxygenases.

Journal of the American Chemical Society·2026
Same author

Experiences of food insecurity among college students caring for children and/or other dependents: a scoping review.

Nutrition research reviews·2026
Same journal

The Population-Based Hungarian Twin Registry: Current Register Data, Researches and Linkages.

Twin research and human genetics : the official journal of the International Society for Twin Studies·2026
Same journal

Abstracts for the 20th Congress of the International Society of Twin Studies, Colombo, Sri Lanka, 10-12 August 2025.

Twin research and human genetics : the official journal of the International Society for Twin Studies·2026
Same journal

THG volume 28 issue 1 Cover.

Twin research and human genetics : the official journal of the International Society for Twin Studies·2026
Same journal

Twins and Look-Alikes: Perspectives on Human Reproductive Cloning/Twin Research Reviews: Infantile Pyknocytosis in a Dizygotic Twin; MZ Twin Discordance for Hemimicrencephaly; Unusual Dental Development, with Expert Commentary; Twin Study of 'Gaze Fingerprint Signatures'/Human Interest: Identical Twin Executives at Odds; Loss of Identical Twin, Jim Whittaker; Identical Twin Artists; Twin Wisdom Captured in Stone.

Twin research and human genetics : the official journal of the International Society for Twin Studies·2026
Same journal

A Systematic Review of Twin Studies in Infants, Children, and Adolescents in Health Research: Focus on South Asia.

Twin research and human genetics : the official journal of the International Society for Twin Studies·2026
Same journal

Multiple-Birth Family Knowledge in Maternity and Child Health Clinics: Filling Knowledge Gaps to Improve Multiple-Birth Family Nursing.

Twin research and human genetics : the official journal of the International Society for Twin Studies·2026
See all related articles
  1. Home
  3. Twin-based Randomized Controlled Trials In Nutritional Research: A Scoping Review.
  1. Home
  3. Twin-based Randomized Controlled Trials In Nutritional Research: A Scoping Review.

Related Experiment Video

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
04:53

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

Twin-Based Randomized Controlled Trials in Nutritional Research: A Scoping Review.

Donya Shahamati1, Jessica Nguyen1, Matthew J Landry1

  • 1Department of Global Health & Biobehavioral Sciences, https://ror.org/04gyf1771Joe C. Wen School of Population & Public Health, University of California, Irvine, Irvine, CA, USA.

Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies
|June 24, 2026

View abstract on PubMed

Summary
This summary is machine-generated.

Twin randomized controlled trials (RCTs) offer a powerful method for nutrition science research. However, these co-twin dietary intervention studies are rare, highlighting a need for increased collaboration and standardized protocols.

Keywords:
Co-twin control designDietary interventionsNutrition researchRandomized controlled trialsTwin studies

Related Experiment Videos

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
04:53

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

Area of Science:

  • Nutritional Science
  • Human Genetics
  • Clinical Trials

Background:

  • Establishing causality in nutrition is challenging due to complex diets and individual variability.
  • Observational studies, common in nutrition, suffer from confounding and measurement errors.
  • Twin-based randomized controlled trials (RCTs), particularly co-twin designs, offer a robust solution to disentangle genetic and environmental factors.

Purpose of the Study:

  • To systematically review twin RCTs in nutrition science.
  • To evaluate the methodological approaches of existing twin RCTs.
  • To identify research gaps and opportunities for future twin-based nutrition studies.

Main Methods:

  • A comprehensive search of clinical trial registries and electronic databases was performed.
  • Eligible studies included co-twin randomized dietary interventions.
  • Studies were classified based on intervention type: dietary patterns, nutrients/supplements, dietary components, or behavioral/multimodal.

    • Main Results:

    • Only 13 eligible twin RCTs were identified, indicating their rarity compared to standard designs.
    • Co-twin randomized dietary interventions are underutilized in nutrition research.
    • Identified interventions spanned dietary patterns, nutrient supplementation, component modification, and behavioral approaches.

    Conclusions:

    • The limited number of twin RCTs in nutrition may stem from recruitment difficulties and generalizability concerns.
    • Increased international collaboration and standardized protocols are needed to advance twin study designs.
    • Integrating emerging technologies can enhance the application and impact of twin designs in nutritional science.