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Protective potential of MMR vaccine against complete Freund's adjuvant-induced inflammation in rats
Rehab S Abd El-Rahman1, Ghada M Suddek, Nariman M Gameil
1Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.
Abstract:
The aim of the present study was to investigate the effect of MMR vaccine on inflammation which was induced by complete Freund's adjuvant (CFA) in male Sprague-Dawley rats. Rats were randomly divided into the control, CFA, MMR and CFA + MMR groups. Inflammatory symptoms such as paw oedema was measured in CFA-injected rats' paw. Body weight changes and alterations in some haematological parameters and oxidative stress markers following CFA injection were checked. In CFA-inflammed rats, there was a significant increase in rat paw thickness and decrease in body weight increment. MMR exhibited a significant anti-inflammatory effect as manifested by reduction in paw thickness and normal gain in body weight when administered 1 week prior to induction of inflammation. The altered haematological parameters (TLC) and oxidative stress markers (MDA, GSH, SOD) in the inflammed rats were significantly brought back to near normal by MMR treatment. In conclusion, MMR vaccine showed a reduction in rat paw thickness and it could significantly normalize the haematological and biochemical abnormalities in CFA-induced inflammatory pain model in rats. Our data suggested that MMR could be a potential protective agent against certain types of inflammatory pain. Further histopathological and radiological studies are required to confirm the possibility of developing novel therapeutic vaccines against some forms of arthritis.
Insights
The Measles, Mumps, and Rubella (MMR) vaccine demonstrated significant anti-inflammatory effects in a rat model. MMR treatment reduced paw swelling and normalized blood markers in rats with induced inflammation.
Area of Science:
- Immunology
- Pharmacology
- Inflammation Research
Background:
- Inflammation is a complex biological response with significant health implications.
- Complete Freund's adjuvant (CFA) is commonly used to induce experimental inflammation in animal models.
- Investigating the immunomodulatory effects of vaccines beyond their primary targets is crucial.
Purpose of the Study:
- To evaluate the anti-inflammatory potential of the Measles, Mumps, and Rubella (MMR) vaccine.
- To assess the impact of MMR on CFA-induced inflammation in Sprague-Dawley rats.
- To determine if MMR can mitigate systemic changes associated with inflammation.
Main Methods:
- Rats were divided into control, CFA, MMR, and CFA + MMR groups.
- Inflammatory response was induced using Complete Freund's Adjuvant (CFA).
- Paw thickness, body weight, hematological parameters (TLC), and oxidative stress markers (MDA, GSH, SOD) were measured.
Main Results:
- CFA injection led to increased paw thickness and decreased body weight gain.
- MMR administration prior to CFA induction significantly reduced paw edema and normalized body weight.
- MMR treatment reversed CFA-induced alterations in TLC, MDA, GSH, and SOD levels.
Conclusions:
- The MMR vaccine exhibits notable anti-inflammatory properties in a CFA-induced rat model.
- MMR effectively mitigates local inflammatory symptoms and systemic biochemical abnormalities.
- MMR may represent a potential therapeutic agent for certain inflammatory conditions, warranting further investigation for conditions like arthritis.
