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Composite intestinal adenoma-microcarcinoid.

Jingmei Lin1, John R Goldblum, Ana E Bennett

  • 1Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA. jinglin@iupui.edu

The American Journal of Surgical Pathology
|November 16, 2011
PubMed
Summary
This summary is machine-generated.

Composite intestinal adenoma and microcarcinoid is a rare neoplasm. While typically indolent, submucosal invasion by the neuroendocrine component may indicate aggressive behavior.

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Area of Science:

  • Gastroenterology
  • Oncology
  • Pathology

Background:

  • Composite intestinal adenoma and microcarcinoid is a rare neoplasm.
  • This entity features intermingled adenomatous and well-differentiated neuroendocrine components.
  • Previous studies suggested an indolent clinical course.

Purpose of the Study:

  • To report morphologic features and clinical follow-up of 7 composite intestinal adenoma-microcarcinoid cases.
  • To evaluate the clinical behavior based on invasion depth.

Main Methods:

  • Retrospective review of 7 cases from a pathology database.
  • Morphologic assessment of biopsy and resection specimens.
  • Clinical follow-up data analysis.

Main Results:

  • Seven cases identified: 5 large intestine, 2 duodenum.
  • All microcarcinoids showed low-grade cytologic atypia.
  • Six cases were mucosa-confined with indolent behavior.
  • One case with submucosal invasion showed metastatic neuroendocrine carcinoma in a lymph node.

Conclusions:

  • Composite mucosa-confined adenoma-microcarcinoid likely has an indolent behavior.
  • Submucosal invasion by the neuroendocrine component may be associated with aggressive behavior.
  • This rare neoplasm requires careful evaluation for invasion depth.