Hematological reference values for healthy adults in togo.

Area of Science:

• Hematology
• Clinical Diagnostics
• Public Health

Background:

• Hematological reference values are essential for accurate medical diagnosis and treatment planning.
• Establishing population-specific reference values is critical, especially in diverse geographical regions like Togo.
• Previous studies may not fully represent the Togolese population due to varying methodologies and inclusion criteria.

Purpose of the Study:

• To determine and report comprehensive hematological reference values for healthy adults in Togo.
• To provide a reliable dataset for clinical laboratories and healthcare providers in the region.
• To facilitate accurate interpretation of blood test results within the Togolese context.

Main Methods:

• A cross-sectional study involving 2571 voluntary blood donors in Togo.
• Rigorous exclusion criteria were applied, including screening for infectious diseases (HIV, HBV, HCV, malaria) and hemoglobinopathies.
• Hematological parameters were analyzed in 1349 definitively retained healthy subjects.

Main Results:

• Median hemoglobin levels were significantly higher in males (15.1 g/dL) than females (13.0 g/dL).
• Median total white blood cell and absolute neutrophil counts were similar between genders.
• Median platelet counts were lower in males (236 × 10^9/L) compared to females (247 × 10^9/L).

Conclusions:

• The established hematological reference values provide a vital resource for Togolese healthcare.
• Observed gender-specific differences in hemoglobin and platelets highlight the need for sex-specific interpretation.
• These values may differ from other African populations due to stringent inclusion criteria, potentially reflecting a healthier cohort free from common deficiencies.