Related Experiment Videos
Randomized split-mouth study on postoperative effects of palmitoylethanolamide for impacted lower third molar surgery
Christian Bacci1, Giulia Cassetta, Bruno Emanuele
1Department of Medical and Surgical Specialities and Unit of Oral Surgery, Institute of Clinical Dentistry, University of Padua, Via Venezia, 90, 35100 Padua, Italy.
ISRN Surgery
|November 16, 2011
Summary
Normast (300 mg) significantly reduced postoperative pain following impacted lower third molar extraction. This study found Normast improved patient recovery, specifically in pain management, after surgical procedures.
Area of Science:
- Oral and Maxillofacial Surgery
- Pharmacology
- Clinical Dentistry
Background:
- Surgical extraction of impacted lower third molars often results in significant postoperative pain and swelling.
- Effective pain management is crucial for improving patient outcomes and satisfaction after dental surgery.
Purpose of the Study:
- To evaluate the efficacy of Normast 300 mg in mitigating pain and swelling after the surgical removal of impacted lower third molars.
- To compare the effects of Normast treatment versus a control on postoperative recovery parameters.
Main Methods:
- A randomized, split-mouth, single-blind study involving 30 patients aged 18-30 undergoing bilateral impacted lower third molar extractions.
- Patients received Normast (300 mg, 2 tablets daily for 15 days) for one extraction site and a control for the other.
- Assessed parameters included trismus, swelling, pain, NSAID consumption, complications, tolerability, and safety, analyzed using repeated measures ANOVA.
Main Results:
- Patients reported significantly less postoperative pain when treated with Normast compared to the control group (P < .0221).
- The trend of pain reduction over time differed significantly between the Normast and control groups (P < .0001).
- No significant differences were observed between Normast and control groups for edema and trismus, although trends differed over time.
Conclusions:
- Normast (300 mg) administration demonstrates significant efficacy in reducing postoperative pain after impacted lower third molar extraction.
- The findings suggest Normast can improve the overall postoperative experience, particularly concerning pain management, for patients undergoing this common surgical procedure.