Related Experiment Video

Updated: May 27, 2026

An Orthotopic Bladder Cancer Model for Gene Delivery Studies
07:48

An Orthotopic Bladder Cancer Model for Gene Delivery Studies

Published on: December 1, 2013

Metastatic bladder cancer: a review of current management

Andrew Fletcher1, Ananya Choudhury, Nooreen Alam

  • 1Department of Palliative and Supportive Care, The Christie NHS Foundation Trust, Wilmslow Road, Manchester M20 4BX, UK.

ISRN Urology
|November 16, 2011
PubMed

Insights

Metastatic bladder cancer management is challenging, with platinum-based chemotherapy as the primary treatment. Future strategies may involve targeted therapies and holistic care to improve patient quality of life.

Area of Science:

  • Oncology
  • Urology

Background:

  • Bladder cancer significantly impacts patient morbidity and mortality.
  • Current advances in metastatic bladder cancer management are limited.
  • Platinum-based chemotherapy is the standard first-line treatment.

Purpose of the Study:

  • To review current management strategies for metastatic bladder cancer.
  • To explore potential future treatment modalities.
  • To discuss the evidence supporting these management approaches.

Main Methods:

  • Literature review of current and emerging treatments for metastatic bladder cancer.
  • Analysis of evidence for chemotherapy, targeted therapies, and supportive care.
  • Discussion of holistic management including radiotherapy and palliative care.

Main Results:

  • Limited survival advantage from alternative chemotherapy regimens.
  • Potential benefit of targeted therapies as single agents or in combination.
  • Importance of holistic management including radiotherapy and palliative care.

Conclusions:

  • Metastatic bladder cancer treatment remains challenging.
  • Targeted therapies represent a promising avenue for future treatment.
  • Comprehensive, holistic care is vital for improving patient quality of life.

More Related Videos

Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development11:02

Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development

Published on: October 30, 2013

Related Concept Videos

Urinary Tract Calculi III: Medical Management01:30

Urinary Tract Calculi III: Medical Management

The diagnosis of renal calculi involves several imaging techniques, including non-contrast CT scans and ultrasound. These methods help visualize kidney stones, assess their size and location, and detect possible obstructions. Additionally, Measuring urine pH is useful for diagnosing specific stone types, such as struvite (alkaline pH) and uric acid stones (acidic pH). Cystine stones are primarily linked to cystinuria, a genetic condition. A urinalysis helps detect blood in the urine (hematuria)...
Urinary Tract Calculi V: Nursing Management01:28

Urinary Tract Calculi V: Nursing Management

AssessmentSubjective Data: Obtain a detailed health history, including any recent or chronic urinary tract infections, periods of immobilization, previous episodes of renal calculi, and medical conditions such as gout, benign prostatic hyperplasia, or hyperparathyroidism. Review the medication history for drugs that may influence stone formation, including allopurinol, analgesics, loop diuretics, or thiazide diuretics. Document the use of long-term indwelling catheters and any past surgical...
Urinary Tract Calculi VI: Surgical Management01:25

Urinary Tract Calculi VI: Surgical Management

Procedures for Kidney StonesMedical intervention is necessary when kidney stones or renal calculi are too large to pass spontaneously (typically greater than 5 millimeters) when stones are accompanied by symptomatic infection (such as fever or pyelonephritis), when they impair kidney function, or when they cause persistent symptoms like severe pain, nausea, or urinary retention. Additionally, patients with only one kidney or those who cannot be treated with medical management also require...
Urinary Tract Infection IV: Nursing Management01:17

Urinary Tract Infection IV: Nursing Management

In managing urinary tract infections (UTIs) in nursing, a comprehensive assessment is essential. Begin by gathering subjective data, such as the patient’s complaints of dysuria (painful urination), urinary frequency, urgency, suprapubic pain, and any lower abdominal discomfort. This information can be complemented by questions regarding previous UTIs, sexual activity, and personal hygiene practices, which can provide insight into risk factors. Objective assessment should focus on signs like...