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Related Concept Videos

Influenza01:27

Influenza

Influenza is an acute, highly communicable viral disease that affects the respiratory tract and is responsible for seasonal epidemics worldwide. Influenza A is the most prevalent type associated with widespread outbreaks and is subtyped based on two surface glycoproteins: hemagglutinin (H) and neuraminidase (N), as in H1N1. These glycoproteins are essential for viral infectivity, transmission, and immune recognition. Transmission occurs primarily through respiratory droplets and contaminated...
Leaky Scanning02:28

Leaky Scanning

During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA.  Marilyn Kozak discovered that the sequence RCCAUGG (where R stands for...

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Related Experiment Video

Updated: May 27, 2026

Fluorescence-based Neuraminidase Inhibition Assay to Assess the Susceptibility of Influenza Viruses to The Neuraminidase Inhibitor Class of Antivirals
09:31

Fluorescence-based Neuraminidase Inhibition Assay to Assess the Susceptibility of Influenza Viruses to The Neuraminidase Inhibitor Class of Antivirals

Published on: April 15, 2017

Influenza neuraminidase.

Gillian M Air1

  • 1Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA. Gillian-air@ouhsc.edu

Influenza and Other Respiratory Viruses
|November 17, 2011
PubMed
Summary

Influenza neuraminidase is a successful antiviral target but an overlooked vaccine target. Including neuraminidase in vaccines may enhance protection against influenza.

Area of Science:

  • Virology
  • Immunology
  • Vaccinology

Background:

  • Influenza neuraminidase is a validated target for licensed antiviral drugs.
  • Several neuraminidase-targeting antivirals are currently in development.
  • Neuraminidase has been largely overlooked as a vaccine target.

Purpose of the Study:

  • To review current knowledge on influenza neuraminidase.
  • To highlight the potential of neuraminidase as a vaccine target.
  • To discuss the structure, enzyme activity, and antigenic significance of neuraminidase.

Main Methods:

  • Literature review of scientific articles on influenza neuraminidase.
  • Analysis of existing data on neuraminidase structure and function.
  • Evaluation of evidence for neuraminidase's role in protective immunity.

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Measuring Influenza Neuraminidase Inhibition Antibody Titers by Enzyme-linked Lectin Assay
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Measuring Influenza Neuraminidase Inhibition Antibody Titers by Enzyme-linked Lectin Assay

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Affinity Purification of Influenza Virus Ribonucleoprotein Complexes from the Chromatin of Infected Cells
11:20

Affinity Purification of Influenza Virus Ribonucleoprotein Complexes from the Chromatin of Infected Cells

Published on: June 3, 2012

Related Experiment Videos

Last Updated: May 27, 2026

Fluorescence-based Neuraminidase Inhibition Assay to Assess the Susceptibility of Influenza Viruses to The Neuraminidase Inhibitor Class of Antivirals
09:31

Fluorescence-based Neuraminidase Inhibition Assay to Assess the Susceptibility of Influenza Viruses to The Neuraminidase Inhibitor Class of Antivirals

Published on: April 15, 2017

Measuring Influenza Neuraminidase Inhibition Antibody Titers by Enzyme-linked Lectin Assay
08:11

Measuring Influenza Neuraminidase Inhibition Antibody Titers by Enzyme-linked Lectin Assay

Published on: September 6, 2016

Affinity Purification of Influenza Virus Ribonucleoprotein Complexes from the Chromatin of Infected Cells
11:20

Affinity Purification of Influenza Virus Ribonucleoprotein Complexes from the Chromatin of Infected Cells

Published on: June 3, 2012

Main Results:

  • Influenza neuraminidase is a key viral surface protein.
  • Neuraminidase plays a critical role in the influenza virus life cycle.
  • Evidence suggests that including neuraminidase in subunit vaccines enhances protective immunity.

Conclusions:

  • Influenza neuraminidase warrants further investigation as a vaccine target.
  • Targeting neuraminidase in vaccines could offer improved influenza protection.
  • A comprehensive understanding of neuraminidase's structure, activity, and antigenicity is crucial for vaccine development.