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Published on: May 28, 2014
Inhibition of TNF-α stimulated nuclear factor-kappa B (NF-κB) activation by cyclometalated platinum(II) complexes
Jia Liu1, Raymond Wai-Yin Sun, Chung-Hang Leung
1Department of Chemistry, State Key Laboratory of Synthetic Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong.
Abstract:
Cyclometalated platinum(II) complexes [Pt(II)(C^N^N)(C≡NR)](+) (HC^N^N = 6-phenyl-2,2'-bipyridyl) display significant inhibition towards TNF-α stimulated NF-κB-dependent gene transcription at concentrations down to the micromolar range.
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