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Related Concept Videos

Liver Regeneration01:24

Liver Regeneration

The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are large...
Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
Renewal of Intestinal Stem Cells01:23

Renewal of Intestinal Stem Cells

The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the goblet,...

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Related Experiment Video

Updated: May 27, 2026

Isolation of CD133+ Liver Stem Cells for Clonal Expansion
12:06

Isolation of CD133+ Liver Stem Cells for Clonal Expansion

Published on: October 10, 2011

[Stem cell-induced liver regeneration].

W T Knoefel1, A Alexander, R Y Tustas

  • 1Heinrich-Heine Universität Düsseldorf, Chirurgische Klinik A, Düsseldorf, Germany. knoefel@uni-duesseldorf.de

Zentralblatt Fur Chirurgie
|November 17, 2011
PubMed
Summary
This summary is machine-generated.

Portal vein embolisation combined with bone marrow stem cell (BMSC) administration significantly enhances liver regeneration in patients with low future liver remnant volume (FLRV). This approach improves hepatic growth rates, potentially enabling safer surgical resections for liver cancer.

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Last Updated: May 27, 2026

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Development of an Ethanol-induced Fibrotic Liver Model in Zebrafish to Study Progenitor Cell-mediated Hepatocyte Regeneration
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Hepatocyte-specific Ablation in Zebrafish to Study Biliary-driven Liver Regeneration
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Hepatocyte-specific Ablation in Zebrafish to Study Biliary-driven Liver Regeneration

Published on: May 20, 2015

Area of Science:

  • Hepatology
  • Regenerative Medicine
  • Surgical Oncology

Background:

  • Liver regeneration is crucial after resection, but critically low future liver remnant volume (FLRV) increases postoperative liver failure risk.
  • Bone marrow stem cells (BMSC) are implicated in liver regeneration.
  • This study investigates augmenting hepatic regeneration using PVE and BMSC in patients with compromised liver function or low FLRV.

Purpose of the Study:

  • To evaluate the efficacy of combining portal vein embolisation (PVE) with CD133+ BMSC administration to enhance liver regeneration.
  • To compare this combined approach with PVE alone in patients with critically low FLRV or impaired liver function.
  • To assess the impact on surgical candidacy and outcomes for patients with malignant liver lesions.

Main Methods:

  • Eleven patients with FLRV below 25% and/or poor liver parenchyma quality underwent PVE of liver segments I and IV-VIII, followed by BMSC administration to segments II and III.
  • A control group received PVE alone.
  • Liver and tumor volumes were measured using helical computed tomography by blinded radiologists to compare FLRV gains.

Main Results:

  • The PVE with BMSC group showed significantly higher absolute FLRV increase (417.1 mL vs. 395.9 mL) and relative FLRV gain (77.3% vs. 39.1%) compared to PVE alone.
  • Daily hepatic growth rate was significantly superior in the PVE with BMSC group (9.5 mL/d vs. 4.1 mL/d).
  • Time to surgery was shorter in the PVE with BMSC group (27 days vs. 45 days), with no negative impact on survival.

Conclusions:

  • Combining PVE with CD133+ BMSC administration significantly augments hepatic regeneration compared to PVE alone in patients with malignant liver lesions.
  • This combined procedure offers potential for safe liver resection in patients at high risk of postoperative liver failure.
  • It expands the possibility of curative-intent surgery for patients with initially unresectable liver tumors due to insufficient liver remnant volume.