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High levels of hsCRP are associated with carbohydrate metabolism disorder

Elba Leiva1, Verónica Mujica, Katherine Brito

  • 1Programa de Investigación de Factores de Riesgo de Enfermedades, Cardiovasculares, Universidad de Talca, Talca, Chile.

Journal of Clinical Laboratory Analysis
|November 17, 2011
PubMed

Insights

High sensitive C-reactive protein (hsCRP) levels are linked to carbohydrate metabolism disturbances. In women with normal glucose, elevated uric acid may signal inflammation and cardiovascular risk.

Area of Science:

  • Cardiovascular Health
  • Metabolic Disorders
  • Inflammation Markers

Background:

  • High sensitive C-reactive protein (hsCRP) is a marker of inflammation.
  • Understanding factors associated with elevated hsCRP is crucial for cardiovascular risk assessment.

Purpose of the Study:

  • To identify risk parameters linked to high hsCRP levels across different fasting glucose statuses.
  • To explore the relationship between hsCRP, glucose metabolism, and other health indicators.

Main Methods:

  • Studied 513 individuals (40-65 years) assessing anthropometrics, blood pressure, glucose, lipids, uric acid, and hsCRP.
  • Employed multivariate linear and logistic regression analyses.
  • Utilized ROC curves to identify cut-off points for uric acid.

Main Results:

  • hsCRP was significantly associated with glycemia, uric acid, diastolic blood pressure, smoking, BMI, and sex.
  • Sex and BMI were key factors for high hsCRP in impaired fasting glucose (IFG) and normoglycemic (NG) subjects.
  • In NG women, uric acid >3.9 mg/dl predicted high hsCRP, indicating a 3.5-fold increased risk.

Conclusions:

  • Elevated hsCRP correlates with carbohydrate metabolism disturbances.
  • In low-risk populations like normoglycemic women, high uric acid (>3.9 mg/dl) may indicate a pro-inflammatory state and heightened cardiovascular risk.
Abstract

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