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Imaging myocardial inflammation of various etiologies with 99mTc-depreotide SPET/CT

Trifon Spyridonidis1, Nikolaos Patsouras, Sotiria Alexiou

  • 1Department of Nuclear Medicine, Cardiology Clinic, University Hospital of Patras, Girokomeiou str. 45, Patras 26500 Greece. tspyr@med.upatras.gr

Hellenic Journal of Nuclear Medicine
|November 17, 2011
PubMed

Previous reports suggested the accumulation of technetium-99m-depreotide trifluoroacetate ((99m)Tc-D) at the sites of active infection or inflammation. Binding of depreotide to over-expressed somatostatin receptors in activated lymphocytes and macrophages probably accounts for the depiction of inflammation. We speculated that myocardial inflammation could also be illustrated by (99m)Tc-D scintigraphy. We report on 3 patients with the clinical diagnosis of myocarditis of various etiologies, in which (99m)Tc-D SPET/CT demonstrated obvious tracer uptake in the myocardium of the left ventricle. In conclusion, we suggest that depreotide imaging can depict myocardial inflammation, thus supporting clinical diagnosis.

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