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Migratory multiple bone involvement in a patient with systemic mastocytosis
1Department of Orthopedic Surgery, Sapir Medical Center, Kfar Saba, Israel.
Clinical Nuclear Medicine
|September 1, 1990
Summary
Systemic mastocytosis can cause severe bone loss and fractures in young patients. Bone scintigraphy with Tc-99m MDP accurately detects disease activity in the skeleton.
Area of Science:
- Skeletal Radiology
- Nuclear Medicine
- Hematology
Background:
- Systemic mastocytosis is a rare disorder characterized by abnormal mast cell accumulation.
- Skeletal involvement, including osteopenia and fractures, can be a significant complication.
Observation:
- A pediatric case of systemic mastocytosis presenting with severe generalized osteopenia and multiple vertebral fractures.
- Clinical, laboratory, and pathological findings confirmed isolated skeletal involvement.
Findings:
- Serial bone scintigraphy using Tc-99m MDP over 6 years revealed migratory axial skeletal lesions.
- These findings indicate active disease progression within the bone.
Implications:
- Tc-99m MDP bone scintigraphy is a valuable tool for monitoring systemic mastocytosis activity in the skeleton.
- Early detection of skeletal involvement aids in timely therapeutic interventions and management.