Related Experiment Video
Updated: Sep 25, 2026

A Practical Guide for the Production and PET/CT Imaging of 68Ga-DOTATATE for Neuroendocrine Tumors in Daily Clinical Practice
Published on: April 17, 2019
18F-FET PET Pitfall in Pituitary Imaging: False-positive Uptake Due to Neurosarcoidosis
Chloé Merino1, Camille Sergeant1, Alexandre Vasiljevic2
1Hospices Civils de Lyon, Service de Médecine Nucléaire, Lyon.
Abstract:
We report a rare pituitary imaging pitfall on 18F-FET PET/CT in a 38-year-old man with a history of treated pulmonary sarcoidosis. MRIs demonstrated a left-sided pituitary neuroendocrine tumor (PitNET)/pituitary adenoma. 18F-FET PET/CT showed discordant bilateral uptake with higher activity on the right side. Histopathological analysis demonstrated a PitNET of corticotroph type on the left side and noncaseating granulomas consistent with sarcoidosis on the right side. Neurosarcoidosis should be considered a potential cause of false-positive 18F-FET uptake.
Related Concept Videos
Positron Emission Tomography
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...
Imaging Studies II: Positron Emission Tomography and Scintigraphy
Fundamental Principles of PET
Radiological Investigation III: Pulmonary Angiogram and PET Scan
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...