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Related Experiment Video

Updated: May 27, 2026

Fabrication of Three-dimensional Paper-based Microfluidic Devices for Immunoassays
11:33

Fabrication of Three-dimensional Paper-based Microfluidic Devices for Immunoassays

Published on: March 9, 2017

Flexible microfluidic cloth-based analytical devices using a low-cost wax patterning technique.

Azadeh Nilghaz1, Dedy H B Wicaksono, Dwi Gustiono

  • 1Medical Device and Implant Technology Group (Mediteg), Dept. of Biomechanics and Biomedical Materials, Faculty of Health Science and Biomedical Engineering, Universiti Teknologi Malaysia, 81310, Johor, Malaysia.

Lab on a Chip
|November 18, 2011
PubMed
Summary

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Researchers developed low-cost microfluidic cloth-based analytical devices (μCADs) using wax patterning on cotton. These flexible devices enable simple colorimetric bioassays, offering a novel platform for diagnostics.

Area of Science:

  • Materials Science
  • Analytical Chemistry
  • Biomedical Engineering

Background:

  • Microfluidic devices offer precise fluid control for bioassays.
  • Existing microfluidic platforms can be expensive and rigid.
  • There is a need for low-cost, flexible, and portable diagnostic tools.

Purpose of the Study:

  • To fabricate novel microfluidic cloth-based analytical devices (μCADs) using cotton fabric.
  • To develop a simple, low-cost method for creating 2D and 3D microfluidic structures on cloth.
  • To demonstrate the utility of μCADs for colorimetric bioassays.

Main Methods:

  • Cotton fabric was treated to enhance wicking properties.
  • Wax patterning was employed to create hydrophobic barriers and hydrophilic channels.

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Non-plasma Bonding of PDMS for Inexpensive Fabrication of Microfluidic Devices
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High Throughput Microfluidic Rapid and Low Cost Prototyping Packaging Methods
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High Throughput Microfluidic Rapid and Low Cost Prototyping Packaging Methods

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Related Experiment Videos

Last Updated: May 27, 2026

Fabrication of Three-dimensional Paper-based Microfluidic Devices for Immunoassays
11:33

Fabrication of Three-dimensional Paper-based Microfluidic Devices for Immunoassays

Published on: March 9, 2017

Non-plasma Bonding of PDMS for Inexpensive Fabrication of Microfluidic Devices
04:45

Non-plasma Bonding of PDMS for Inexpensive Fabrication of Microfluidic Devices

Published on: November 1, 2007

High Throughput Microfluidic Rapid and Low Cost Prototyping Packaging Methods
07:51

High Throughput Microfluidic Rapid and Low Cost Prototyping Packaging Methods

Published on: December 23, 2013

  • 2D and 3D microfluidic devices were fabricated through heat transfer and folding techniques.
  • Colorimetric detection of bovine serum albumin (BSA) in artificial urine was performed.

    • Main Results:

    • Successfully fabricated 2D and 3D microfluidic devices on cotton cloth.
    • Demonstrated improved wicking properties after soda ash treatment.
    • Achieved colorimetric detection of BSA using bromophenol blue (BPB).
    • Showcased device functionality even when bent, highlighting flexibility.

    Conclusions:

    • Cotton cloth is a viable, inexpensive, and flexible platform for microfluidic devices.
    • The wax patterning method is simple, low-cost, and requires no specialized equipment.
    • μCADs are suitable for developing portable and accessible diagnostic assays.