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Updated: May 27, 2026

Induction and Validation of Cellular Senescence in Primary Human Cells
Published on: June 20, 2018
Stem cell senescence and regenerative paradigms
A P Beltrami1, D Cesselli, C A Beltrami
1Department of Medical and Biological Sciences, University of Udine, Udine, Italy. antonio.beltrami@uniud.it
Abstract:
The term "cellular senescence" denotes a cellular response to several stressors that results in irreversible growth arrest, alterations of the gene expression profile, epigenetic modifications, and an altered secretome, all of which eventually impair the reparative properties of primitive cells, adding a layer of complexity to the field of regenerative medicine. The purpose of this review is to illustrate how cellular senescence could affect tissue repair and to propose interventions that aim at interfering with it.
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