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Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography
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Right ventricular dysplasia: Right and left ventricular involvement morphometrically evaluated.

C A Beltrami1, N Finato, V D Mea

  • 1Dipartimento di Ricerche Mediche e Morfologiche-Anatomia Patologica, Universitá degli Studi di Udine, Italy.

Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology
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Summary

Right ventricular dysplasia (RVD) involves adipose tissue replacing heart muscle. This study reveals extensive fat infiltration in both ventricles, leading to heart failure in a donor heart transplant patient.

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Area of Science:

  • Cardiology
  • Pathology
  • Cardiac Morphology

Background:

  • Right ventricular dysplasia (RVD) is a cardiac anomaly where adipose tissue replaces right ventricular myocardium.
  • While primarily affecting the right ventricle, minor left ventricular abnormalities have been reported.

Purpose of the Study:

  • To investigate the morphometric distribution of adipose tissue in both ventricles in a case of unsuspected RVD.
  • To elucidate the structural basis of heart failure in RVD.

Main Methods:

  • Morphometric analysis of the donor heart.
  • Evaluation of fat distribution and ventricular remodeling.

Main Results:

  • Extensive, homogeneous adipose tissue replacement of the right ventricle.
  • Significant adipose tissue infiltration in the left ventricle, predominantly at the apex.
  • Cardiac remodeling characterized by right ventricular volume increase and myocyte elongation.

Conclusions:

  • RVD can extensively affect both ventricles, presenting a structural basis for congestive heart failure.
  • The findings highlight the importance of recognizing RVD in cardiac transplantation and understanding its pathological mechanisms.