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Updated: May 27, 2026

Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase
Published on: November 23, 2016
2-Cyano-N'-(2-hy-droxy-3-meth-oxy-benzyl-idene)acetohydrazide
1College of Chemistry and Biology Engineering, Yancheng Institute of Technology, Yancheng 224051, People's Republic of China.
Abstract:
The title compound, C(11)H(11)N(3)O(3), was obtained by the reaction of 3-meth-oxy-salicyl-aldehyde with cyano-acetohydrazide in methanol. There is an intra-molecular O-H⋯N hydrogen bond in the mol-ecule. In the crystal, mol-ecules are linked by N-H⋯O hydrogen bonds, generating chains running along the b axis.
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The IUPAC and common names of amides are derived from the parent carboxylic acid, by replacing the suffix “oic acid” and “ic acid,” respectively, with “amide.” In the following example, the IUPAC name ethanamide is derived from ethanoic acid, and the common name, acetamide, is obtained from acetic acid.
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Carboxylic acid derivatives contain an acyl group attached to a heteroatom such as chlorine, oxygen, or nitrogen. The carbonyl carbon and oxygen are both sp2-hybridized with an unhybridized p orbital.
The three sp2 orbitals of the carbonyl carbon form three σ bonds, one each with the carbonyl oxygen, the α carbon, and the heteroatom, whereas the other two sp2 orbitals of the carbonyl oxygen are occupied by the lone pairs. Further, the unhybridized p...
Carboxylic Acids to Methylesters: Alkylation using Diazomethane

