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Solid Lipid Nanoparticles (SLNs) for Intracellular Targeting Applications
08:19

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Published on: November 17, 2015

Surface-modified solid lipid nanoparticulate formulation for ifosfamide: development and characterization.

Ambrish A Pandit1, Alekha K Dash

  • 1Department of Pharmacy Sciences, School of Pharmacy & Health Professions, Creighton University, 2500 California Plaza, Omaha, NE 68178, USA.

Nanomedicine (London, England)
|November 19, 2011
PubMed
Summary
This summary is machine-generated.

Surface-modified solid lipid nanoparticles (SLNs) using glyceryl monooleate and chitosan enhance ifosfamide stability and release. These SLNs show improved cellular uptake and permeability for potential therapeutic applications.

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Area of Science:

  • Nanotechnology
  • Pharmaceutical Sciences
  • Drug Delivery

Background:

  • Ifosfamide is a hydrophilic drug requiring improved delivery systems for enhanced stability and sustained release.
  • Solid lipid nanoparticles (SLNs) offer a promising platform for drug delivery but require surface modification for optimal performance.

Purpose of the Study:

  • To develop and characterize surface-modified SLNs using glyceryl monooleate (GMO) and chitosan for ifosfamide delivery.
  • To evaluate the stability, drug release kinetics, cellular permeability, and subcellular localization of ifosfamide-loaded SLNs.

Main Methods:

  • SLNs were prepared using a double emulsion technique with GMO and chitosan, crosslinked with sodium tripolyphosphate, and lyophilized under varied vacuum conditions.
  • Physicochemical characterization included morphology, particle size, surface charge, and moisture content.
  • In vitro drug release, stability, cellular permeability (Caco-2 cells), and subcellular localization were assessed.

Main Results:

  • Lyophilization conditions influenced SLN morphology and moisture content.
  • The developed SLNs exhibited high encapsulation efficiency and sustained release of ifosfamide.
  • Enhanced stability, significant cellular uptake, and improved permeability of ifosfamide were observed in Caco-2 cells.

Conclusions:

  • GMO and chitosan-based SLNs are effective in enhancing the stability and sustained release of ifosfamide.
  • These surface-modified SLNs demonstrate potential for improved drug targeting and permeability characteristics.