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Melanotic neuroectodermal tumor of infancy.
Kelly R Magliocca1, Robert M Pfeifle, Indraneel Bhattacharyya
1Department of Oral and Maxillofacial Diagnostic Sciences, University of Florida, Gainesville, Florida 32610, USA. cottrk@hotmail.com
Pediatric Dermatology
|November 19, 2011
Summary
Melanotic neuroectodermal tumor of infancy (MNTI) is a rare pediatric lesion. This case report details an MNTI occurring in a 6-month-old boy's anterior maxilla.
Area of Science:
- Pediatric Oncology
- Oral Pathology
- Dermatology
Background:
- Melanotic neuroectodermal tumor of infancy (MNTI) is a rare, benign, pigmented tumor of neural crest origin.
- It predominantly affects infants and children, typically presenting within the first year of life.
- MNTI commonly occurs in the head and neck region, particularly the maxilla and mandible.
Observation:
- This report describes a case of MNTI in a 6-month-old male infant.
- The tumor presented as a lesion in the anterior maxilla.
- The clinical presentation and histopathologic features were consistent with MNTI.
Findings:
- Histopathologic examination revealed characteristic features of MNTI, including nests of large, pigmented cells with vesicular nuclei and prominent nucleoli, interspersed with smaller, non-pigmented cells.
- Immunohistochemical analysis supported the diagnosis, showing positivity for markers such as S100 and HMB-45.
- Radiographic imaging demonstrated a well-defined, intraosseous lesion.
Implications:
- Early diagnosis and appropriate management are crucial for favorable outcomes in MNTI.
- This case highlights the importance of considering MNTI in the differential diagnosis of pediatric jaw lesions.
- Further research into the etiology and optimal treatment strategies for MNTI is warranted.
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