Related Experiment Video
Updated: May 27, 2026

Examining BCL-2 Family Function with Large Unilamellar Vesicles
Published on: October 5, 2012
Expression of apoptosis regulatory proteins p53, bcl-2 and bax in recurrent aphthous ulceration
J F N Pinto Rodrigues1, C T Fujiyama Oshima, A P Ribeiro Paiotti
1Departamentos de Patologia Biociências, Universidade Federal de Sao Paulo - UNIFESP, Sao Paulo, Brazil.
Background:
Recurrent aphthous ulceration (RAU) is considered to be an acute inflammatory disease of unknown pathogenesis. Apoptosis may represent an important event in the control of inflammation.
Objectives:
The aim of this study was to investigate apoptosis process in RAU using immunohistochemistry.
Methods:
We studied the expression and location of p53, bcl-2 and bax in ulcerated lesions clinically diagnosed as RAU (n = 12) and compared it with that of oral clinically normal mucosa (n = 6) and of other inflammatory chronic disease such as oral fibrous inflammatory hyperplasia (FIH; n = 18).
Results:
Significant statistically differences (n < 0.05) in p53 expression were noticed in RAU when compared with normal mucosa. No significant statistically differences (P > 0.05) were noticed between FIH and RAU. Bcl-2 and bax did not show remarkable differences between groups.
Conclusions:
Taken together, the data suggest that RAU induces p53 immunoexpression. Therefore, the protein might be related to the aetiopathogenesis of the ulcerated oral lesions.
Related Concept Videos
The Intrinsic Apoptotic Pathway
The Extrinsic Apoptotic Pathway
Abnormal Proliferation
Inflammatory Bowel Disease II: Ulcerative Colitis
Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors
Cellular Injury V: Apoptosis and Autophagy
