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Related Experiment Videos

Behavioral modification of colonic function. Can constipation be learned?

A G Klauser1, W A Voderholzer, C A Heinrich

  • 1Department of Gastroenterology, University of Munich, Germany.

Digestive Diseases and Sciences
|October 1, 1990
PubMed
Summary
This summary is machine-generated.

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Voluntarily suppressing defecation significantly reduces bowel movement frequency and stool weight. This suppression also slows colonic transit time, particularly in the rectosigmoid and right hemicolon, potentially mimicking constipation.

Area of Science:

  • Gastroenterology
  • Physiology

Background:

  • Understanding colonic motility and the effects of defecation habits is crucial for diagnosing and treating functional bowel disorders.
  • Previous hypotheses suggested that defecation could be suppressed long-term and that this might impact colonic motility.

Purpose of the Study:

  • To investigate the effects of voluntary, prolonged defecation suppression on colonic motility.
  • To test the hypotheses that defecation can be suppressed and that this suppression affects upper colonic motility.

Main Methods:

  • A randomized, two-week study involving 12 male volunteers with controlled nutrition and physical activity.
  • Comparison of defecation frequency, stool weight, and colonic transit times (total and segmental) during a week of normal defecation versus a week of voluntary defecation suppression, using radiopaque markers.

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Main Results:

  • Defecation frequency and stool weight were significantly lower during the suppression week.
  • Total colonic transit time increased from 28.8 to 53.1 hours.
  • Segmental transit times increased in the rectosigmoid and right hemicolon during defecation suppression.

Conclusions:

  • Voluntary suppression of defecation can alter colonic function, potentially contributing to conditions like constipation.
  • Functional anorectal outlet obstruction may influence right colon activity, possibly through reflex mechanisms.