Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...

Acute Coronary Syndrome III: Diagnostic Studies

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...

Pericarditis II: Clinical Features and Diagnostic Tests

Pericarditis II: Clinical Features and Diagnostic Tests

Pericarditis is distinguished by inflammation of the pericardium, the fibrous sac that encases the heart. It can be acute, lasting less than six weeks, or chronic, persisting for over three months. Understanding its clinical manifestations and diagnostic findings is crucial for timely and effective management.Clinical ManifestationsWhile pericarditis can be asymptomatic, it usually presents with characteristic symptoms such as:Chest Pain: The most characteristic symptom of pericarditis is chest...

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...

Enzyme-Linked Immunosorbent Assay

Enzyme-Linked Immunosorbent Assay

In 1971, Peter Perlman and Eva Engvall developed an Enzyme-linked immunosorbent assay (ELISA or EIA). ELISA differs from western blot in that the assays are conducted in microtiter plates or in vivo rather than on an absorbent membrane.
There are many different types of ELISAs, but they all involve an antibody molecule whose constant region binds an enzyme, leaving the variable region free to bind its specific antigen. Enzyme-substrate reaction allows the antigen to be visualized or quantified.

Clinical Trials

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Rational design of Gd-doped Eu-MOF for enhanced gallic acid sensing.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy·2026

Same author

Biological Effects of High-Frequency Electromagnetic Fields on CNS Function and Neuroimmune Responses: A Systematic Review of In Vitro and In Vivo Experimental Studies.

Neurotoxicity research·2026

Same author

Transcobalamin receptor CD320, responsible for vitamin B<sub>12</sub> cellular uptake, is present on the cell surface as a homo-oligomer.

The Journal of biological chemistry·2026

Same author

Biomarker Based ARIA Stress Test: A Proposed Conceptual Framework for Dynamic Biomarker-Guided ARIA Risk Stratification in Anti-Amyloid Immunotherapy for Alzheimer's Disease.

Journal of molecular neuroscience : MN·2026

Same author

Thromboembolic risk in subcutaneous versus intravenous immunoglobulin therapy: a systematic review and narrative meta-synthesis.

Clinical and experimental medicine·2026

Same author

Radiomics model for risk stratification of intracranial aneurysm: a high-resolution vessel wall imaging-based study.

BMC medical imaging·2026

Search research articles

Related Experiment Video

Updated: May 27, 2026

Standardized SDS-PAGE Workflow for Personalized Protein Corona Profiling in Early Cancer Detection

Standardized SDS-PAGE Workflow for Personalized Protein Corona Profiling in Early Cancer Detection

Published on: December 19, 2025

Corin in clinical laboratory diagnostics.

Ningzheng Dong¹, Shenghan Chen, Wei Wang

¹Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, First Affiliated Hospital, Soochow University, Suzhou, China. ningzheng_dong@yahoo.com.cn

Clinica Chimica Acta; International Journal of Clinical Chemistry

|November 19, 2011

Summary

Corin, an enzyme in the heart, regulates blood pressure and cardiac function. Reduced levels of soluble corin in blood may indicate heart failure (HF), suggesting its potential as a diagnostic biomarker.

More Related Videos

Point-of-care CRISPR-based Diagnostics with Premixed and Freeze-dried Reagents

Point-of-care CRISPR-based Diagnostics with Premixed and Freeze-dried Reagents

Published on: August 16, 2024

Related Experiment Videos

Last Updated: May 27, 2026

Standardized SDS-PAGE Workflow for Personalized Protein Corona Profiling in Early Cancer Detection

Standardized SDS-PAGE Workflow for Personalized Protein Corona Profiling in Early Cancer Detection

Published on: December 19, 2025

Point-of-care CRISPR-based Diagnostics with Premixed and Freeze-dried Reagents

Point-of-care CRISPR-based Diagnostics with Premixed and Freeze-dried Reagents

Published on: August 16, 2024

Area of Science:

Cardiovascular Biology
Enzymology
Biomarker Discovery

Background:

Corin is a heart-specific serine protease that activates natriuretic peptides, crucial for blood pressure and cardiac function.
Corin activity is tightly regulated through multiple cellular mechanisms, including transcriptional control and protein trafficking.
Corin deficiency is implicated in the pathogenesis of heart disease.

Purpose of the Study:

To review the function and regulation of corin in the heart.
To discuss the significance of soluble corin detected in human blood.
To explore the potential of soluble corin as a biomarker for heart failure (HF).

Main Methods:

Review of existing literature on corin's function and regulation.
Analysis of studies investigating corin levels in animal models and human patients.
Examination of research on soluble corin in blood and its association with HF.

Main Results:

Corin plays a vital role in maintaining cardiovascular homeostasis.
Soluble corin levels are decreased in patients with heart failure (HF).
These findings suggest a link between corin deficiency and HF development.

Conclusions:

Corin is essential for normal cardiac function and blood pressure regulation.
Reduced soluble corin levels in blood may serve as a potential biomarker for diagnosing and monitoring heart failure (HF).
Further research into soluble corin could lead to novel diagnostic strategies for cardiovascular diseases.