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Updated: May 27, 2026

Identification and Analysis of Mouse Erythroid Progenitors using the CD71/TER119 Flow-cytometric Assay
Published on: August 5, 2011
The pleiotropic effects of erythropoietin in infection and inflammation
Manfred Nairz1, Thomas Sonnweber, Andrea Schroll
1Department of Internal Medicine I, Clinical Immunology and Infectious Diseases, Innsbruck Medical University, Anichstr. 35, A-6020 Innsbruck, Austria.
Abstract:
Erythropoietin (EPO) is a multi-functional cytokine, which exerts erythropoietic effects but also carries anti-apoptotic and immune-modulatory activities upon binding to two distinct receptors which are expressed on erythroid, parenchymal and immune cells, respectively. Whereas EPO ameliorates hemolytic anemia in malaria or trypanosomiasis and improves the course of autoimmune diseases such as inflammatory bowel disease or autoimmune encephalomyelitis, it deleteriously inhibits macrophage functions in Salmonella infection in animal models. Thus, the specific modulation of extra-erythropoietic EPO activity forms an attractive therapeutic target in infection and inflammation.
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