Ambient temperature affects thrombotic potential at rest and following exercise
Paul R Nagelkirk1, Kyla B Hogan, Joanna M Hoare
1School of Physical Education, Sport & Exercise Science, Ball State University, Muncie, IN 47306-0270, USA. prnagelkirk@bsu.edu
Thrombosis Research
|November 19, 2011
Summary
Cold temperatures increase blood coagulation potential during maximal exercise, elevating ischemic event risk. This study investigated hemostasis changes in hot, temperate, and cold conditions.
Area of Science:
- Exercise Physiology
- Hemostasis and Thrombosis
- Environmental Extremes
Background:
- Exercise increases ischemic risk due to altered coagulation and fibrinolysis.
- Ambient temperature's effect on resting thrombotic potential is known, but its impact during exercise remains unclear.
- This study addresses the gap in understanding heat and cold effects on exercise-induced hemostasis.
Purpose of the Study:
- To assess changes in coagulation and fibrinolysis during maximal exercise in hot, cold, and temperate conditions.
- To compare the hemostatic responses to exercise across different ambient temperatures.
Main Methods:
- Fifteen healthy men performed maximal exercise tests in hot (30°C), temperate (20°C), and cold (5-8°C) environments.
- Blood samples were collected pre- and post-exercise.
- Analyzed for thrombin-antithrombin III (TAT), active tissue plasminogen activator (tPA), and plasminogen activator inhibitor-1 (PAI-1) concentrations.
Main Results:
- Significant increases in TAT and tPA activity were observed from pre- to post-exercise across all temperatures.
- TAT concentrations were significantly higher in cold conditions compared to temperate and hot conditions.
- A trend for PAI-1 response to exercise was noted, but did not reach statistical significance.
Conclusions:
- Coagulation potential is elevated during exercise in cold temperatures.
- These findings suggest an increased risk of ischemic events in cold environments during physical exertion.
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