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Related Concept Videos

Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and narrowing...
Transient Ischemic Attack l: Introduction01:26

Transient Ischemic Attack l: Introduction

A transient ischemic attack (TIA) is a brief episode of neurological dysfunction caused by a temporary, focal reduction in cerebral blood flow. Although symptoms resemble those of an ischemic stroke, the interruption in perfusion is short-lived and does not cause permanent infarction. TIAs are clinically important because they often serve as early warning events for future stroke.Mechanisms of Transient Cerebral IschemiaTransient cerebral ischemia may arise through several mechanisms. One...
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...

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Related Experiment Video

Updated: May 27, 2026

Myocardial Infarction and Functional Outcome Assessment in Pigs
12:03

Myocardial Infarction and Functional Outcome Assessment in Pigs

Published on: April 25, 2014

[Sequential double vessel myocardial infarction].

Hélder Ribeiro1, Catarina Ferreira, Ana Batista

  • 1Serviço de Cardiologia, Centro Hospitalar de Trás-os-Montes e Alto Douro, Unidade de Vila Real, Vila Real, Portugal. hjmribeiro@gmail.com

Revista Portuguesa De Cardiologia : Orgao Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology
|November 19, 2011
PubMed
Summary
This summary is machine-generated.

Double infarction, or acute myocardial infarction (AMI) affecting two areas simultaneously, is rare. This phenomenon may stem from the prothrombotic and inflammatory state associated with AMI, often leading to fatal outcomes before hospital admission.

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Myocardial Infarction and Functional Outcome Assessment in Pigs
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In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
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Published on: February 16, 2016

Area of Science:

  • Cardiology
  • Cardiovascular Medicine
  • Thrombosis Research

Background:

  • Acute myocardial infarction (AMI) is a critical condition involving heart muscle ischemia.
  • Double infarction, affecting two vascular territories concurrently, is a recognized but infrequently reported complication of AMI.

Observation:

  • Simultaneous transmural ischemia in two distinct vascular territories during AMI is a rare clinical event.
  • High mortality rates associated with extensive myocardial injury from multiple vessel obstruction may explain underreporting.

Findings:

  • Double infarction is speculated to arise from the systemic prothrombotic and inflammatory milieu present in AMI.
  • The pro-inflammatory and pro-thrombotic state in AMI may predispose individuals to simultaneous infarction in multiple coronary territories.

Implications:

  • Understanding the mechanisms of double infarction is crucial for improving outcomes in complex AMI cases.
  • Further research into the prothrombotic and inflammatory pathways in AMI could identify novel therapeutic targets to prevent extensive myocardial damage.