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Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay
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CDK5 interacts with Slo and affects its surface expression and kinetics through direct phosphorylation.

Jun-Ping Bai1, Alexei Surguchev, Powrnima Joshi

  • 1Department of Neurology, Yale University School of Medicine, New Haven, CT 06510, USA.

American Journal of Physiology. Cell Physiology
|November 19, 2011
PubMed
Summary

Cyclin-dependent kinase 5 (CDK5) interacts with the Slo α-subunit of large-conductance calcium-activated potassium (BK) channels. CDK5 regulates BK channel surface expression and kinetics in hair cells, impacting electrical tuning.

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