Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Morphogenesis02:19

Morphogenesis

Plant morphogenesis—the development of a plant’s form and structure—involves several overlapping developmental processes, including growth and cell differentiation. Precursor cells differentiate into specific cell types, which are organized into the tissues and organ systems that make up the functional plant.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Identifying strategic opportunities through the development of a roadmap for additive manufacturing: The example of Portugal.

Heliyon·2023
Same author

Lower low density lipoprotein cholesterol associates to higher mortality in non-diabetic heart failure patients.

International journal of cardiology. Cardiovascular risk and prevention·2023
Same author

Negative impact on the reproductive potential of blue jack mackerel Trachurus picturatus by Kudoa infection of the ovary.

Diseases of aquatic organisms·2020
Same author

Asthma App Use and Interest Among Patients With Asthma: A Multicenter Study.

Journal of investigational allergology & clinical immunology·2020
Same author

Histologically validated scoring system for the assessment of hock burn in broilers.

Avian pathology : journal of the W.V.P.A·2020
Same author

Chromatin three-dimensional interactions mediate genetic effects on gene expression.

Science (New York, N.Y.)·2019
Same journal

Evolution of quantitative traits: exploring the ecological, social and genetic bases of adaptive polymorphism.

Journal of theoretical biology·2026
Same journal

The male-biased sex ratio in humans and its role in the transition from promiscuity to pair bonding.

Journal of theoretical biology·2026
Same journal

Quantifying the counter-intuitive effects of vaccination by coupling the transmission dynamics of COVID-19 and the evolution of human behaviors.

Journal of theoretical biology·2026
Same journal

An integrative model of FGF2-induced signaling and muscle cell proliferation.

Journal of theoretical biology·2026
Same journal

A hybrid reaction-diffusion and mechanical stimulus model for mandibular bone remodeling under chewing and vibratory loading.

Journal of theoretical biology·2026
Same journal

Integrated tick management strategies in fragmented peridomestic environments.

Journal of theoretical biology·2026
See all related articles

Related Experiment Video

Updated: May 27, 2026

Creating Objects and Object Categories for Studying Perception and Perceptual Learning
14:38

Creating Objects and Object Categories for Studying Perception and Perceptual Learning

Published on: November 2, 2012

Modeling morphogen gradient formation from arbitrary realistically shaped sources.

S Dalessi1, A Neves, S Bergmann

  • 1Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland; Swiss Institute of Bioinformatics, Switzerland.

Journal of Theoretical Biology
|November 19, 2011
PubMed
Summary
This summary is machine-generated.

This study presents a new mathematical framework for modeling morphogen gradient formation from any source, improving upon simplistic point-source assumptions. The research demonstrates that extended or dynamic sources yield more realistic Bicoid gradients in Drosophila embryos.

More Related Videos

Using Confocal Analysis of Xenopus laevis to Investigate Modulators of Wnt and Shh Morphogen Gradients
08:10

Using Confocal Analysis of Xenopus laevis to Investigate Modulators of Wnt and Shh Morphogen Gradients

Published on: December 14, 2015

Probing the Roles of Physical Forces in Early Chick Embryonic Morphogenesis
06:33

Probing the Roles of Physical Forces in Early Chick Embryonic Morphogenesis

Published on: June 5, 2018

Related Experiment Videos

Last Updated: May 27, 2026

Creating Objects and Object Categories for Studying Perception and Perceptual Learning
14:38

Creating Objects and Object Categories for Studying Perception and Perceptual Learning

Published on: November 2, 2012

Using Confocal Analysis of Xenopus laevis to Investigate Modulators of Wnt and Shh Morphogen Gradients
08:10

Using Confocal Analysis of Xenopus laevis to Investigate Modulators of Wnt and Shh Morphogen Gradients

Published on: December 14, 2015

Probing the Roles of Physical Forces in Early Chick Embryonic Morphogenesis
06:33

Probing the Roles of Physical Forces in Early Chick Embryonic Morphogenesis

Published on: June 5, 2018

Area of Science:

  • Developmental Biology
  • Mathematical Biology
  • Biophysics

Background:

  • Current morphogen modeling often uses simplified point-source assumptions.
  • One-dimensional, steady-state solutions are frequently considered, neglecting source dynamics and spatial extent.

Purpose of the Study:

  • To develop a general mathematical formalism for modeling diffusive gradient formation from arbitrary sources.
  • To apply this framework to the Bicoid gradient in Drosophila embryos.
  • To analyze the impact of source characteristics on morphogen profiles.

Main Methods:

  • Utilized the Green's function method for a general diffusion problem formalism.
  • Modeled Bicoid gradient formation involving protein translation, diffusion, and linear degradation.
  • Derived analytical expressions for steady-state and time-dependent one-dimensional problems.

Main Results:

  • Extended sources (finite or Gaussian) produce more realistic morphogen gradients than point sources.
  • Steady-state solutions align with a decreasing exponential profile.
  • Dynamic sources can achieve protein profiles similar to static sources.

Conclusions:

  • The developed Green's function formalism offers a versatile approach to modeling morphogen gradients.
  • Source characteristics significantly influence gradient profiles, with extended and dynamic sources providing more biologically relevant patterns.
  • This work refines our understanding of gradient formation mechanisms in developmental biology.